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Background and Objectives: calcium is the most abundant mineral in the body, making up nearly 2% of total body weight. This element has several roles in organisms. Manganese is an essential trace element which is taken part in the structure of some metal enzymes. There is a little evidence for deficiency of manganese in human, whereas its toxicity has been reported in several cases. Since, calcium interference with intestinal absorption of manganese can influences processes such as bone formation and growth, thus in the present project, this matter has been investigated.Methods: In this study interrelationship between calcium and manganese intestinal absorption by everted gut sac technique, has been studied. Animals were fasted 24h prior to the experiments and small intestine was removed. The intestine cut into adequate pieces and the segments were everted. The everted gut sacs were suspended in kerebs- ringer – phosphate medium. Results: incubation of freshly prepared E.G.S in kerebs ringer phosphate (KRP) medium PH 7.4 containing either calcium or manganese showed that incubation time. The absorption of metal Ions is a dose dependent process and maximum absorption carried out in the presence of 1.50 or 1.85 mM of calcium or manganese respectively. Addition of calcium to reaction mixture reduced manganese absorption by 35 percent. Whereas manganese decreased calcium absorption by approximately 20 %. The effects of citrate and glucose on intestinal absorption of calcium and manganese have been investigated here. Conclusion: the data of present study indicate that calcium and manganese can interference each other intestinal absorption.